https://larry-leon.r-universe.devRecent package updates in larry-leonR-universehttps://github.com/larry-leon.pnghttps://larry-leon.r-universe.devFri, 30 Oct 2026 02:39:17 GMTlarry.leon.05@post.harvard.edu (Larry Leon)Implements statistical methods for exploratory subgroup identification in clinical trials. Provides tools for identifying patient subgroups with differential treatment effects using machine learning approaches including Generalized Random Forests (GRF), LASSO regularization, and exhaustive combinatorial search algorithms. Supports survival endpoints (Cox proportional hazards), binary outcomes (log odds ratio, log relative risk, risk difference), continuous outcomes (mean difference), and count / rate outcomes (log incidence rate ratio via Poisson, quasi-Poisson, or negative-binomial GLMs with optional person-time offset). Features bootstrap bias correction using infinitesimal jackknife methods to address selection bias in post-hoc analyses. Designed for clinical researchers conducting exploratory subgroup analyses in randomized controlled trials, particularly for multi-regional clinical trials (MRCT) requiring regional consistency evaluation. Methods are described in Leon et al. (2024) <doi:10.1002/sim.10163>. Post-selection inference for the identified subgroup follows León and Anderson (2026) <doi:10.48550/arXiv.2609.38361>. The search methodology is given in León and Anderson (2026) <doi:10.48550/arXiv.2610.28379>.https://github.com/r-universe/larry-leon/actions/runs/41029484557Fri, 30 Oct 2026 02:39:17 GMTforestsearch0.4.1successhttps://larry-leon.r-universe.devhttps://github.com/larry-leon/forestsearchforestsearch.qmdforestsearch.htmlInterpretable subgroup identification with forestsearch2026-02-10 01:14:422026-10-28 20:44:19larry.leon.05@post.harvard.edu (Larry Leon)Provides survival analysis functions with support for time-dependent and subject-specific (e.g., propensity score) weighting. Implements weighted estimation for Cox models, Kaplan-Meier survival curves, and treatment differences with point-wise and simultaneous confidence bands. Includes restricted mean survival time (RMST) comparisons evaluated across all potential truncation times with both point-wise and simultaneous confidence bands. See Cole, S. R. & Hernán, M. A. (2004) <doi:10.1016/j.cmpb.2003.10.004> for methodological background.https://github.com/r-universe/larry-leon/actions/runs/40876297140Thu, 12 Feb 2026 18:28:14 GMTweightedsurv0.1.0successhttps://larry-leon.r-universe.devhttps://github.com/larry-leon/weightedsurvweightedsurv_examples.Rmdweightedsurv_examples.htmlWeighted Survival Analysis Examples2025-11-18 20:05:052026-02-12 03:35:15